Glioblastoma - Involves Cerebral Cortex, White matter & Midline of Corpus Callosum

Glioblastoma is a highly aggressive, infiltrating primary malignant tumor of the adult brain, typically arising in the cerebral hemispheres and extensively involving the white matter. Grossly, it often appears heterogeneous because of necrosis and hemorrhage, with infiltration into surrounding brain tissue. Tumor spread across the corpus callosum may involve both cerebral hemispheres, producing the characteristic "butterfly" pattern. Patients may present with headache, seizures, cognitive or personality changes, focal neurological deficits and features of raised intracranial pressure. Rapid progression may cause marked cerebral edema, mass effect, midline shift and brain herniation.