Transverse Section - Corpus Callosum & Septum Pellucidum

The corpus callosum is the largest bundle of commissural white-matter fibres in the brain, connecting corresponding areas of the right and left cerebral hemispheres and allowing rapid exchange of sensory, motor and cognitive information. The septum pellucidum is a thin, translucent, double-layered membrane situated beneath the corpus callosum. It separates the frontal horns of the two lateral ventricles. A small potential space may persist between its layers as the cavum septum pellucidum. Traumatic shearing forces can damage callosal fibres, particularly in diffuse axonal injury (DAI). Corpus callosal lesions may also occur in demyelination, infarction and toxic–metabolic disorders. Abnormalities or persistence of the cavum septum pellucidum may be encountered on neuroimaging and at autopsy, but should always be interpreted with the overall clinical and pathological findings.